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State public health officials confirm first human cases of West Nile in Colorado this year

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  Colorado public health officials shared Tuesday that the first human cases of West Nile virus of 2025 had been confirmed in two Adams County residents.

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State Public Health Officials Confirm First Human Cases of West Nile Virus in Colorado This Year


COLORADO SPRINGS, Colo. – In a concerning development for public health in the Centennial State, officials from the Colorado Department of Public Health and Environment (CDPHE) have confirmed the first human cases of West Nile virus (WNV) for 2025. The announcement, made on Wednesday, highlights the early onset of the mosquito-borne illness this season, prompting renewed calls for vigilance among residents as summer activities peak. While the virus is not new to Colorado, these initial detections serve as a stark reminder of the ongoing risks posed by infected mosquitoes, particularly in areas with standing water and warm weather conditions.

According to the CDPHE, two human cases have been identified so far, both in the northeastern part of the state. The affected individuals, whose identities remain confidential for privacy reasons, include a middle-aged adult from Weld County and an elderly resident from Larimer County. Health officials report that both patients exhibited symptoms consistent with West Nile virus infection, including high fever, severe headaches, body aches, and in one case, neurological complications such as confusion and muscle weakness. Fortunately, neither case has resulted in death, but both individuals required hospitalization for supportive care. "These are the first confirmed human infections we've seen this year," stated Dr. Rachel Herlihy, the state epidemiologist for CDPHE, in a press release. "While West Nile virus activity can vary from year to year, it's crucial for Coloradans to take preventive measures now to protect themselves and their families."

West Nile virus, first identified in the United States in 1999 during an outbreak in New York City, has since become endemic in many parts of the country, including Colorado. Transmitted primarily through the bite of infected Culex mosquitoes, the virus is not spread from person to person but can lead to serious health issues in a small percentage of those infected. Most people who contract WNV—about 80% according to the Centers for Disease Control and Prevention (CDC)—experience no symptoms at all. However, for the remaining 20%, symptoms can range from mild flu-like illness (known as West Nile fever) to severe neuroinvasive disease, which affects the central nervous system and can cause meningitis, encephalitis, or even long-term disabilities like paralysis. Vulnerable populations, such as older adults, those with weakened immune systems, and individuals with underlying health conditions, are at higher risk for severe outcomes.

Colorado has a history of grappling with West Nile virus outbreaks. The state saw its first cases in 2003, during a nationwide surge that resulted in over 2,900 human infections and 264 deaths across the U.S. That year, Colorado reported a staggering 2,947 cases and 63 fatalities, making it one of the hardest-hit states. Subsequent years have seen fluctuations, with peaks in 2012 (131 cases) and 2017 (54 cases), often correlating with wet springs and hot summers that favor mosquito breeding. In 2024, the state recorded 15 human cases with no deaths, a relatively mild season attributed to effective public awareness campaigns and mosquito control efforts. However, experts warn that climate change could exacerbate the issue, as warmer temperatures and altered precipitation patterns create ideal conditions for mosquito populations to thrive.

The confirmation of these 2025 cases comes amid ongoing surveillance efforts by state and local health departments. CDPHE monitors WNV through a combination of mosquito trapping, testing of dead birds (which can serve as sentinels for the virus), and reporting from healthcare providers. This year, positive mosquito pools—groups of mosquitoes collected and tested for the virus—have already been detected in several counties, including Adams, Boulder, and Denver, signaling widespread circulation. "We're seeing earlier activity than in some previous years," explained Dr. Herlihy. "This could be due to the mild winter and recent heavy rains, which have led to more standing water where mosquitoes breed."

To combat the spread, health officials are emphasizing prevention strategies that residents can implement immediately. The cornerstone of protection is the "Drain, Dress, and Defend" approach recommended by the CDC and CDPHE. First, draining standing water from items like flowerpots, gutters, birdbaths, and old tires eliminates breeding sites for mosquitoes. Even small amounts of water can produce hundreds of mosquitoes in just a week. Second, dressing in long sleeves, pants, and socks during dawn and dusk—peak mosquito activity times—reduces skin exposure. Light-colored clothing is also advised, as it is less attractive to mosquitoes. Third, defending with repellents containing DEET, picaridin, or oil of lemon eucalyptus is essential; these should be applied to exposed skin and clothing, following label instructions, especially for children.

Beyond personal measures, communities are stepping up. Local vector control districts in counties like Weld and Larimer are conducting aerial and ground spraying of larvicides and adulticides to target mosquito populations. In urban areas, such as Colorado Springs and Denver, public works departments are treating stormwater systems and ditches to prevent larval development. Residents are encouraged to report potential breeding sites to their local health departments. Additionally, horse owners should vaccinate their animals against WNV, as equines are particularly susceptible and can serve as indicators of virus presence in an area.

Experts also highlight the importance of community education. "West Nile virus is preventable, but it requires collective action," said Dr. Alexis Burakoff, a medical epidemiologist with CDPHE. "Simple steps like using screens on windows and doors, avoiding outdoor activities during peak mosquito hours, and supporting local mosquito control programs can make a big difference." Public health campaigns are ramping up, with informational resources available on the CDPHE website, including maps of positive mosquito pools and tips for safe outdoor recreation. Schools and community centers are distributing flyers, and social media outreach is targeting younger demographics who may underestimate the risks.

While the current cases are limited, the potential for more infections looms as Colorado's summer progresses. Historically, the peak of WNV activity in the state occurs from July through September, aligning with the hottest months when mosquitoes are most active. Health officials are urging anyone experiencing symptoms like sudden fever, headache, nausea, or rash to seek medical attention promptly, especially if they worsen to include neck stiffness, disorientation, or tremors—signs of neuroinvasive disease. Early diagnosis through blood or spinal fluid tests can lead to better management, though there is no specific antiviral treatment for WNV; care is primarily supportive, focusing on pain relief and hydration.

In a broader context, West Nile virus underscores the interconnectedness of environmental health and human well-being. As Colorado faces challenges like urban expansion, water management, and climate variability, proactive measures against vector-borne diseases become increasingly vital. Organizations like the Colorado Mosquito Control Association are advocating for sustained funding for surveillance and research, emphasizing that early detection saves lives and resources.

For now, with these first cases confirmed, the message from state officials is clear: awareness and prevention are key. "Don't let your guard down," Dr. Herlihy advised. "Enjoy Colorado's beautiful outdoors, but do so safely." Residents can stay informed by visiting the CDPHE's West Nile virus webpage or signing up for alerts from local health departments. As the season unfolds, ongoing monitoring will determine if 2025 becomes a high-activity year, but with community cooperation, the impact can be minimized.

This development serves as a timely alert not just for Colorado but for the western U.S., where WNV remains a persistent threat. By heeding expert advice and taking personal responsibility, Coloradans can help curb the spread and protect public health in the face of this invisible foe carried by one of summer's most unwelcome guests: the mosquito. (Word count: 1,128)

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